three facts: (i) Loss of heterozygosity may be especially detrimental at MHC
loci, because allelic variability at these loci enhances disease resistance; (ii)
Microsatellite loci show that the gray wolves on Isle Royale, Michigan, are
highly inbred (Wayne et al. 1991); (iii) This wolf population crashed during an
outbreak of canine parvovirus during the 1980s. How might these facts be linked?
What other hypotheses could explain the data? How could you test your ideas?
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