A 13-year-old exhibited developmental delay, learning disabilities, mood swings, and at times, autistic behavior when he was younger. His current physical exam shows a long face, large ears, and large, fleshy hands. His fingers exhibit hyperextensible joints. Examination of fibroblasts cultured from the boy showed abnormal DNA damage, but only in the absence of folic acid. This disorder has, at the genetic level, which one of the following? (A) A single missense mutation (B) A large deletion (C) An extended triplet nucleotide repeat (D) A nonsense mutation (E) Gene inactivation via methylation
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