A 5-year-old presents to the pediatrician due to lethargy and tiredness. The red blood cell count is

A 5-year-old presents to the pediatrician due to lethargy and tiredness. The red blood cell count is normal, but molecular analysis indicates that the child is producing 25% of the normal amount of a-globin, compared to 100% of the normal amount of _globin. Further analysis shows a total deletion of the a-globin genes from one chromosome. What might account for the lower than expected levels of a-globin being produced? (A) _globin inhibition of a-globin synthesis (B) Enhanced expression of ?-globin synthesis (C) Loss of a _globin gene (D) Deletion of a third a-globin gene (E) Duplication

A 5-year-old presents to the pediatrician due to lethargy and tiredness. The red blood cell count is normal, but molecular analysis indicates that the child is producing 25% of the normal amount of a-globin, compared to 100% of the normal amount of _globin. Further analysis shows a total deletion of the a-globin genes from one chromosome. What might account for the lower than expected levels of a-globin being produced? (A) _globin inhibition of a-globin synthesis (B) Enhanced expression of ?-globin synthesis (C) Loss of a _globin gene (D) Deletion of a third a-globin gene (E) Duplication of an a-globin gene

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