A human geneticist is studying two different families. In one family, all of the children of a mildly affected mother display myoclonic epilepsy, developmental display, and abnormal muscle biopsy (ragged red fibers). In the other family, the three children of an affected woman endure strokelike episodes and a mitochondrial myopathy. The common link between these two diseases is which of the following? (A) Mutations in pyruvate dehydrogenase complex (B) Mutations in cytoplasmic tRNA (C) Mutations in mitochondrial tRNA (D) Mutations in malate dehydrogenase (E) Mutations in pyruvate carboxylase
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