An artificial pacemaker provides an electrical stimulus to bring cardiac muscle cells to threshold..

An artificial pacemaker
provides an electrical stimulus to bring cardiac muscle cells to threshold and
initiate action potentials when the pacemaker cells in the heart are not
working properly. Suppose that the pacemaker provides a current applied as a
square-wave pulse (consider it to be a step input, as you are only interested
in the sudden increase in current). The cell membrane can be modeled as a
resistor and capacitor in parallel, as shown in Figure 5.76.You want to bring
the membrane potential up from -90mV to the
threshold value of -55mV (after which the Na+
channels open and the
»

An artificial pacemaker
provides an electrical stimulus to bring cardiac muscle cells to threshold and
initiate action potentials when the pacemaker cells in the heart are not
working properly. Suppose that the pacemaker provides a current applied as a
square-wave pulse (consider it to be a step input, as you are only interested
in the sudden increase in current). The cell membrane can be modeled as a
resistor and capacitor in parallel, as shown in Figure 5.76.You want to bring
the membrane potential up from -90mV to the
threshold value of -55mV (after which the Na+
channels open and the action potential begins), so you need to apply a voltage
of 35 mV. The value of the membrane resistance is 3300_ and the membrane capacitance is 1.5mF. If you want
the increase in voltage to occur within 5 ms, what should be the value of the
applied current (im)?

 

»

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